Human Oxysterol-binding Protein-related Protein 3, OSBPL3 ELISA Kit

SKU: E3359Hu

Size:96 Tests-1 Kit

Background:Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed: 16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed: 25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed: 18270267, PubMed: 25447204). With VAPA, may regulate ER morphology (PubMed: 16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed: 18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed: 16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed: 17428193).

Research_area:Others

Applications:ELISA

Target_protein:OSBPL3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.053ng/ml

Detection range:0.1-38ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Oxysterol-Binding Protein-Related Protein 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9H4L5

MASS(Da):101,224

GeneID:26031

Synonyms:ORP-3;OSBPL 3;OSBPL3;OSBP-related protein 3;Oxysterol-binding protein-related protein 3

Gene names:OSBPL3

Standard solution:40ng/ml