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GeneBio Systems

Human Nlr Family, Card Domain Containing 3, NLRC3 ELISA Kit

Human Nlr Family, Card Domain Containing 3, NLRC3 ELISA Kit

E6709Hu

$848.00 USD
$848.00 USD
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Size:96 Tests-1 Kit

Background:Negative regulator of the innate immune response (PubMed: 15705585, PubMed: 22863753, PubMed: 25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed: 22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed: 22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed: 25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed: 25277106).

Research_area:Immunology

Applications:ELISA

Target_protein:NLRC3

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.84ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nlr Family, Card Domain Containing 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q7RTR2

MASS(Da):114,658

GeneID:197358

Synonyms:CARD15-like protein;Caterpiller protein 16.2;CLR16.2;NACHT, LRR and CARD domains-containing protein 3;NLR family CARD domain-containing protein 3;NLRC 3;NLRC3;Nucleotide-binding oligomerization domain protein 3

Gene names:NLRC3

Standard solution:3200ng/L

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