Human Neuropilin-1, NRP1 ELISA Kit

SKU: E2101Hu

Size:96 Tests-1 Kit

Background:Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins (PubMed: 9288753, PubMed: 9529250, PubMed: 10688880). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed: 19805273). It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed: 9288753, PubMed: 9529250, PubMed: 10688880, PubMed: 19805273). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed: 30623799). [Isoform 2]: Binds VEGF-165 and may inhibit its binding to cells (PubMed: 10748121, PubMed: 26503042). May induce apoptosis by sequestering VEGF-165 (PubMed: 10748121). May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection.

Research_area:Others

Applications:ELISA

Target_protein:NRP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.054ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Neuropilin-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14786

MASS(Da):103,134

GeneID:8829

Synonyms:CD antigen CD304;Neuropilin-1;NRP 1;NRP1;Vascular endothelial cell growth factor 165 receptor

Gene names:NRP1

Standard solution:48ng/ml