Human Neurogenic Differentiation Factor 1, NEUROD1 ELISA Kit

SKU: E2920Hu

Size:96 Tests-1 Kit

Background:Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:NEUROD1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Neurogenic Differentiation Factor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13562

MASS(Da):39,920

GeneID:4760

Synonyms:bHLHa3;Class A basic helix-loop-helix protein 3;NeuroD;NEUROD 1;NEUROD1;Neurogenic differentiation factor 1

Gene names:NEUROD1

Standard solution:24ng/ml