Human Nectin-4/PVRL4 ELISA Kit PicoKine®

SKU: EK1536

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: NECTIN4

Specificity: Natural and recombinant human Nectin-4

Background: Nectin-4, also known as PVRL4, is an adhesion receptor of the immunoglobulin superfamily and functions in cell-cell adhesion. This gene is mapped to chromosome 1q23.3. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Immunogen: Expression system for standard: NS0; Immunogen sequence: G32-S349

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Reference:

Uniprot ID: Q96NY8

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 81607

Protein Name: Nectin-4

Gene Full Name: nectin cell adhesion molecule 4

Synonyms: Ig superfamily receptor LNIR; LNIR; nectin 4; Nectin-4; poliovirus receptor related 4; PRR4; PVRL4