Human Nadphoxidase 4, NOX4 ELISA Kit

SKU: E4156hu

Size:96 Tests-1 Kit

Background:Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium Channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. [Isoform 4]: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:NOX4

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.36ng/L

Detection range:5-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Nadph Oxidase 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NPH5

MASS(Da):66,932

GeneID:50507

Synonyms:Kidney oxidase-1;Kidney superoxide-producing NADPH oxidase;KOX-1;NADPH oxidase 4;NOX 4;NOX4;Renal NAD(PH-oxidase

Gene names:NOX4

Standard solution:1600ng/L