Human Myeloid Cell Surface Antigen Cd33, CD33 ELISA Kit

SKU: E5714Hu

Size:96 Tests-1 Kit

Background:Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed: 10611343, PubMed: 15597323, PubMed: 11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans (PubMed: 7718872). Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed: 28325905, PubMed: 10887109). These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed: 10556798, PubMed: 10206955, PubMed: 10887109). In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules (PubMed: 10206955, PubMed: 10887109). One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K (PubMed: 15597323).

Research_area:Immunology

Applications:ELISA

Target_protein:CD33

Reactivity:Human

Assay type:Sandwich

Sensitivity:23.55ng/L

Detection range:70-15000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Myeloid Cell Surface Antigen CD33

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P20138

MASS(Da):39,825

GeneID:945

Synonyms:CD 33;CD antigen CD33;CD33;gp67;Myeloid cell surface antigen CD33;Sialic acid-binding Ig-like lectin 3;Siglec-3

Gene names:CD33

Standard solution:16000ng/L