Human MICB ELISA Kit PicoKine®

SKU: EK0963

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: MICB

Specificity: Natural and recombinant human MICB

Background: MHC class I polypeptide-related sequence B, also called MICB is a protein that in humans is encoded by the MICB gene. The MICB gene is mapped to 6p21.33. This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. It seems to have no role in antigen presentation. This gene acts as a stress-induced self-antigen that is recognized by gamma delta T cells. It is the ligand for the KLRK1/NKG2D receptor and binds to KLRK1 leads to cell lysis.

Immunogen: Expression system for standard: NS0; Immunogen sequence: A23-G298

Clonality:

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Reconstitution:

Reference:

Uniprot ID: Q29980

Host:

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Conjugate:

Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Clone Number:

Observed Molecular Weight:

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Gene ID: 4277

Protein Name: MHC class I polypeptide-related sequence B

Gene Full Name: MHC class I polypeptide-related sequence B

Synonyms: MIC B; MICB; PERB11.2