Human Methionine Synthase, MTR ELISA Kit

SKU: E3942Hu

Size:96 Tests-1 Kit

Background:Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed: 27771510). MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (PubMed: 27771510). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine Synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed: 27771510).

Research_area:Metabolism

Applications:ELISA

Target_protein:MTR

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.027ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Methionine Synthase

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99707

MASS(Da):140,527

GeneID:4548

Synonyms:5-methyltetrahydrofolate--homocysteine methyltransferase;Cobalamin-dependent methionine Synthase;Methionine Synthase;MS;MTR;Vitamin-B12 dependent methionine Synthase

Gene names:MTR

Standard solution:24ng/ml