Human Matrix-Remodeling-associated Protein 8, MXRA8 ELISA Kit

SKU: E5650Hu

Size:96 Tests-1 Kit

Background:Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed: 22492581, PubMed: 23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed: 23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed: 23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed: 23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity). (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses.

Research_area:Cell Biology

Applications:ELISA

Target_protein:MXRA8

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Matrix-Remodeling-Associated Protein 8

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BRK3

MASS(Da):49,132

GeneID:54587

Synonyms:Limitrin;Matrix remodeling-associated protein 8;MXRA 8;MXRA8

Gene names:MXRA8

Standard solution:24ng/ml