Human Map, Microtubule Affinity-Regulating Kinase 4, MARK4 ELISA Kit

SKU: E6736Hu

Size:96 Tests-1 Kit

Background:Serine/threonine-protein kinase (PubMed: 15009667, PubMed: 14594945, PubMed: 23666762, PubMed: 23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed: 14594945, PubMed: 23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed: 14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed: 14594945, PubMed: 25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed: 23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed: 23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed: 25123532). Reduces neuronal cell survival (PubMed: 15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed: 23184942).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:MARK4

Reactivity:Human

Assay type:Sandwich

Sensitivity:14.22ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Map,Microtubule Affinity-Regulating Kinase 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96L34

MASS(Da):82,520

GeneID:57787

Synonyms:MAP/microtubule affinity-regulating kinase 4;MAP/microtubule affinity-regulating kinase-like 1;MARK 4;MARK4

Gene names:MARK4

Standard solution:6400ng/L