Human Lysine-specific Demethylase 5A, KDM5A ELISA Kit

SKU: E5611Hu

Size:96 Tests-1 Kit

Background:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:KDM5A

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.03ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Lysine-specific demethylase 5A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P29375

MASS(Da):192,095

GeneID:5927

Synonyms:Histone demethylase JARID1A;Jarid1A;Jumonji/ARID domain-containing protein 1A;KDM5A;Lysine-specific demethylase 5A;RBBP2;RBBP-2;RBP2;Retinoblastoma-binding protein 2;

Gene names:KDM5A

Standard solution:3200ng/L