Human Low Density Lipoprotein Receptor Related Protein 5, LRP5 ELISA Kit

SKU: E4697Hu

Size:96 Tests-1 Kit

Background:Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins (PubMed: 11336703, PubMed: 11448771, PubMed: 15778503, PubMed: 11719191, PubMed: 15908424, PubMed: 16252235). Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed: 11336703, PubMed: 11719191). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (By similarity). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed: 11719191). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (PubMed: 11336703, PubMed: 25920554, PubMed: 24706814, PubMed: 14731402). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (PubMed: 27228167, PubMed: 16252235). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:LRP5

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.72ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Low Density Lipoprotein Receptor Related Protein 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75197

MASS(Da):179,145

GeneID:4041

Synonyms:Low-density lipoprotein receptor-related protein 5;Low-density lipoprotein receptor-related protein 7;LRP 5;LRP5;LRP-5;LRP-7

Gene names:LRP5

Standard solution:1600ng/L