Human Klotho beta/KLB ELISA Kit PicoKine®

SKU: EK1492

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: KLB

Specificity: Natural and recombinant human Klotho beta

Background: Klotho beta, a divergent structural member of the glycosidase I superfamily, is expressed primarily in the liver and pancreas, with lower expression in adipose tissue. It is mapped to chromosome 4. The Klotho beta mediated interaction of human FGF19 (mouse FGF15) with FGF Receptor 4 in the liver negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes, cholesterol 7-alpha hydroxylase (Cyp7a1) and sterol 12-alpha hydroxylase (Cyp8b1). Klotho beta is also an essential cofactor for FGF21 activity and the Klotho gene family may have evolved to confer tissue-specific bioactivity on FGF19 subfamily members.

Immunogen: Expression system for standard: NS0; Immunogen sequence: F53-L997

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Reference:

Uniprot ID: Q86Z14

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 152831

Protein Name: Beta-klotho

Gene Full Name: klotho beta

Synonyms: Beta-klotho; Betaklotho; BKL; KLB; Klotho beta