Human Kindlin 1, KIND1 ELISA Kit

SKU: E2773Hu

Size:96 Tests-1 Kit

Background:Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed: 2$458.00|$300.009551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed: 21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Research_area:Others

Applications:ELISA

Target_protein:SPIN1

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.11ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Kindlin 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Y657

MASS(Da):29,601

GeneID:10927

Synonyms:Ovarian cancer-related protein;SPIN 1;SPIN1;Spindlin1;Spindlin-1

Gene names:SPIN1

Standard solution:6400ng/L