Human Interferon Regulatory Factor 8, IRF8 ELISA Kit

SKU: E0417Hu

Size:96 Tests-1 Kit

Background:Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed: 25122610). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells (PubMed: 29434592).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:IRF8

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.44ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interferon Regulatory Factor 8

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q02556

MASS(Da):48,356

GeneID:3394

Synonyms:H-ICSBP;ICSBP;Interferon consensus sequence-binding protein;Interferon regulatory factor 8;IRF 8;IRF8;IRF-8

Gene names:IRF8

Standard solution:1280ng/L