Human Interferon-induced Helicase C Domain-containing Protein 1, IFIH1 ELISA Kit

SKU: E4251hu

Size:96 Tests-1 Kit

Background:Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Detects coronavirus SARS-CoV-2 (PubMed: 24686847). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

Research_area:Others

Applications:ELISA

Target_protein:IFIH1

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.23ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interferon-Induced Helicase C Domain-Containing Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BYX4

MASS(Da):116,689

GeneID:64135

Synonyms:CADM-140 autoantigen;Clinically amyopathic dermatomyositis autoantigen 140 kDa;Helicard;Helicase with 2 CARD domains;IFIH 1;IFIH1;Interferon-induced helicase C domain-containing protein 1;Interferon-induced with helicase C domain protein 1;MDA-5;Melanoma differentiation-associated protein 5;Murabutide down-regulated protein;RIG-I-like receptor 2;RLR-2;RNA helicase-DEAD box protein 116

Gene names:IFIH1

Standard solution:2400ng/L