Human Histone Deacetylase 6, HDAC6 ELISA Kit

SKU: E2131Hu

Size:96 Tests-1 Kit

Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed: 10220385). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed: 10220385). Histone deacetylases act via the formation of large multiprotein complexes (PubMed: 10220385). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed: 12024216, PubMed: 20308065). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed: 30538141). Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed: 24413532). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed: 17846173). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed: 17846173).

Research_area:Others

Applications:ELISA

Target_protein:HDAC6

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.31ng/ml

Detection range:0.5-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Histone Deacetylase 6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UBN7

MASS(Da):131,419

GeneID:10013

Synonyms:HD6;HDAC 6;HDAC6;Histone deacetylase 6;Tubulin-lysine deacetylase HDAC6

Gene names:HDAC6

Standard solution:48ng/ml