Human Heterogeneous Nuclear Ribonucleoprotein K, HNRNP K ELISA Kit

SKU: E5399Hu

Size:96 Tests-1 Kit

Background:One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

Research_area:Others

Applications:ELISA

Target_protein:hnRNP K

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.33ng/mL

Detection range:0.5-200ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:heterogeneous nuclear ribonucleoprotein K

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P61978

MASS(Da):50,976

GeneID:3190

Synonyms:AUKS;CSBP;Heterogeneous nuclear ribonucleoprotein K;hnRNP K;HNRPK;Transformation up-regulated nuclear protein;TUNP

Gene names:HNRNPK

Standard solution:256ng/mL