Human Heat Shock 70kDa Protein 1 Like Protein,HSPA1L ELISA KIT

SKU: E3006Hu

Size:96 Tests-1 Kit

Background:Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810). {ECO:0000269|PubMed:24270810, ECO:0000303|PubMed:26865365}.

Research_area:

Applications:ELISA

Target_protein:HSPA1L

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Heat Shock 70kDa Protein 1 Like Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P34931

MASS(Da):70375

GeneID:3305

Synonyms:HSPA1L

Gene names:HSPA1L

Standard solution:24ng/ml