Human Gtpase Kras, KRAS ELISA Kit

SKU: E6448Hu

Size:96 Tests-1 Kit

Background:The KRAS (Kirsten rat sarcoma virus) gene provides instructions for making a protein called K-Ras, part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate). The K-Ras protein is a GTPase, which means it converts a molecule called GTP into another molecule called GDP. In this way the K-Ras protein acts like a switch that is turned on and off by the GTP and GDP molecules. To transmit signals, it must be turned on by attaching (binding) to a molecule of GTP. The K-Ras protein is turned off (inactivated) when it converts the GTP to GDP. When the protein is bound to GDP, it does not relay signals to the cell's nucleus. It is called KRAS because it was first identified as an oncogene in Kirsten RAt Sarcoma virus. The viral oncogene was derived from cellular genome. Thus, KRAS gene in cellular genome is called a proto-oncogene.

Research_area:Others

Applications:ELISA

Target_protein:KRAS

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.39ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:GTPase KRas

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P01116

MASS(Da):21,656

GeneID:3845

Synonyms:CFC2;c-Ki-ras;c-Ki-ras2;C-K-RAS;GTPase KRas;GTPase KRas, N-terminally processed];KI-RAS;KRAS;K-Ras;K-Ras 2;KRAS2;K-RAS2A;K-RAS2B;K-RAS4A;K-RAS4B;NS;NS3;OES;RALD;RASK2

Gene names:KRAS

Standard solution:1600ng/L