Human Gremlin 1, GREM1 ELISA Kit

SKU: E2735Hu

Size:96 Tests-1 Kit

Background:Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed: 27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:GREM1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.025ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Gremlin 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O60565

MASS(Da):20,697

GeneID:26585

Synonyms:Cell proliferation-inducing gene 2 protein;Cysteine knot superfamily 1, BMP antagonist 1;DAN domain family member 2;Down-regulated in Mos-transformed cells protein;GREM 1;GREM1;Gremlin-1;IHG-2;Increased in high glucose protein 2;

Gene names:GREM1

Standard solution:24ng/ml