Human Glutamate receptor 2,GRIA2 ELISA KIT

SKU: E6972Hu

Size:96 Tests-1 Kit

Background:Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system (PubMed:31300657). It plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P19491, ECO:0000269|PubMed:20614889, ECO:0000269|PubMed:31300657}.

Research_area:

Applications:ELISA

Target_protein:GRIA2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.054ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Glutamate receptor 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P42262

MASS(Da):98821

GeneID:2891

Synonyms:GRIA2 GLUR2

Gene names:GRIA2

Standard solution:48ng/ml