Human Frizzled-6, FZD6 ELISA Kit

SKU: E2367Hu

Size:96 Tests-1 Kit

Background:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:FZD6

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.58ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Frizzled-6

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O60353

MASS(Da):79,292

GeneID:8323

Synonyms:Frizzled-6;FZ6;FZ-6;FZD6;HFZ6;NDNC1;NDNC10

Gene names:FZD6

Standard solution:4800ng/L