Human Free fatty acid receptor 1,FFAR1 ELISA KIT

SKU: E5103Hu

Size:96 Tests-1 Kit

Background:G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. {ECO:0000250|UniProtKB:Q76JU9, ECO:0000269|PubMed:12496284, ECO:0000269|PubMed:17699519, ECO:0000269|PubMed:23809162, ECO:0000269|PubMed:24130766, ECO:0000269|PubMed:24742677}.

Research_area:

Applications:ELISA

Target_protein:FFAR1

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.01ng/mL

Detection range:1.88-120ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Free fatty acid receptor 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14842

MASS(Da):31457

GeneID:2864

Synonyms:FFAR1 GPR40

Gene names:FFAR1

Standard solution:240ng/mL