Human Excitatory amino acid transporter 3,SLC1A1 ELISA KIT

SKU: E6635Hu

Size:96 Tests-1 Kit

Background:Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7914198, ECO:0000269|PubMed:8857541}.

Research_area:

Applications:ELISA

Target_protein:SLC1A1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.81ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Excitatory amino acid transporter 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P43005

MASS(Da):57100

GeneID:6505

Synonyms:SLC1A1 EAAC1 EAAT3

Gene names:SLC1A1

Standard solution:4000ng/L