Human Ephrin Type-A Receptor 4, EPHA4 ELISA Kit

SKU: E4550Hu

Size:96 Tests-1 Kit

Background:Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:EPHA4

Reactivity:Human

Assay type:Sandwich

Sensitivity:6.97ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ephrin Type-A Receptor 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P54764

MASS(Da):109,860

GeneID:2043

Synonyms:EK8;EPHA 4;EPHA4;EPH-like kinase 8;Ephrin type-A receptor 4;hEK8;Tyrosine-protein kinase receptor SEK;Tyrosine-protein kinase TYRO1

Gene names:EPHA4

Standard solution:3200ng/L