Human EGFR PicoKine® Quick ELISA Kit

SKU: FEK0327

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: EGFR

Specificity: Natural and recombinant human EGFR

Background: The epidermal growth factor receptor(EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family(EGF-family) of extracellular protein ligands.1 It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR(ErbB-1), HER2/c-neu(ErbB-2), Her 3(ErbB-3) and Her 4(ErbB-4). EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha(TGFalpha). EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to EGFR overexpression(known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed.

Immunogen: Expression system for standard: NS0; Immunogen sequence: M1-S645

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Reconstitution:

Reference:

Uniprot ID: P00533

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 1956

Protein Name: Epidermal growth factor receptor

Gene Full Name: epidermal growth factor receptor

Synonyms: EGFR; ERBB; ERBB1; HER1; mENA; PIG61; Proto oncogene c ErbB 1