Human DKK-4 / Dickkopf 4 ELISA Kit PicoKine®

SKU: EK0868

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: DKK4

Specificity: Natural and recombinant human DKK-4

Background: DKK4 is a membersof the Dickkopf family which are negative regulators of the growth-promoting Wnt / beta-catenin signaling pathway. By FISH, the DKK4 gene was mapped to chromosome 8p11.2-p11.1. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. The expression of DKK4 was significantly reduced in hepatocellular carcinomas (HCCs), particularly in HCCs that showed cytoplasmic beta- catenin accumulation. DKK4 expression was also reduced in HCC cell lines. Ectopic expression of DKK4 in 2 HCC cell lines reduced beta-catenin and cyclin D1 protein levels and attenuated beta-catenin activity in reporter gene assays.

Immunogen: Expression system for standard: NS0; Immunogen sequence: L19-L224

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Reference:

Uniprot ID: Q9UBT3

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 27121

Protein Name: Dickkopf-related protein 4

Gene Full Name: dickkopf Wnt signaling pathway inhibitor 4

Synonyms: Dickkopf 4; Dickkopf related protein 4; DKK 4; DKK4; hDkk 4