Human Dickkopf-1, DKK1 ELISA Kit

SKU: E0630Hu

Size:96 Tests-1 Kit

Background:Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed: 22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed: 17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

Research_area:Cardiovascular

Applications:ELISA

Target_protein:DKK1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.26ng/ml

Detection range:0.5-150ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Dickkopf-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O94907

MASS(Da):28,672

GeneID:22943

Synonyms:Dickkopf-1;Dickkopf-related protein 1;DKK 1;DKK1;Dkk-1;hDkk-1;SK

Gene names:DKK1

Standard solution:160ng/ml