Human Diablo/SMAC ELISA Kit PicoKine®

SKU: EK0838

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: DIABLO

Specificity: Natural and recombinant human Diablo

Background: Diablo homolog, mitochondrial, also known as second mitochondria-derived activator of caspases (SMAC), is a protein that in humans is encoded by the DIABLO gene ( IAP binding protein with low pI). It is mapped to 12q24.31. DIABLO can bind mammalian IAP homolog A (MIHA, or API3) and can also interact with MIHB, MIHC, and OpIAP, the baculoviral IAP. This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Over expression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: A56-D239

Clonality:

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Reconstitution:

Reference:

Uniprot ID: Q9NR28

Host:

Concentration:

Conjugate:

Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Clone Number:

Observed Molecular Weight:

Calculated Molecular Weight:

Gene ID: 56616

Protein Name: Diablo IAP-binding mitochondrial protein

Gene Full Name: diablo IAP-binding mitochondrial protein

Synonyms: Diablo homolog; mitochondrial; DIABLO S; SMAC; SMAC3