Human Complement Factor I, CFI ELISA Kit

SKU: E3502Hu

Size:96 Tests-1 Kit

Background:Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three Peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins (PubMed: 7360115, PubMed: 17320177). Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces (PubMed: 2141838, PubMed: 9605165, PubMed: 12055245). The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization (PubMed: 28671664).

Research_area:Immunology

Applications:ELISA

Target_protein:CFI

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.42ng/mL

Detection range:3-900ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Complement Factor I

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P05156

MASS(Da):65,750

GeneID:3426

Synonyms:C3B/C4B inactivator;CFI;Complement factor I;Complement factor I heavy chain;Complement factor I light chain

Gene names:CFI

Standard solution:960ng/mL