Human Complement Component 5, C5 ELISA Kit

SKU: E0347Hu

Size:96 Tests-1 Kit

Background:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed: 8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Research_area:Others

Applications:ELISA

Target_protein:C5

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.021mg/ml

Detection range:0.05-10mg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Complement Component 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P01031

MASS(Da):188,305

GeneID:727

Synonyms:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4;C5;C5a anaphylatoxin;Complement C5;Complement C5 alpha chain;Complement C5 alpha' chain;Complement C5 beta chain

Gene names:C5

Standard solution:12.8mg/ml