Human Complement C5a Anaphylatoxin,C5 ELISA KIT

SKU: E6722Hu

Size:96 Tests-1 Kit

Background:Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. {ECO:0000269|PubMed:8182049}.

Research_area:

Applications:ELISA

Target_protein:C5

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.54ng/mL

Detection range:1-400ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Complement C5a Anaphylatoxin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P01031

MASS(Da):188305

GeneID:727

Synonyms:C5 CPAMD4

Gene names:C5

Standard solution:480ng/mL