Human Cofilin-1, CFL1 ELISA Kit

SKU: E4625Hu

Size:96 Tests-1 Kit

Background:Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed: 11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed: 15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed: 2183$498.00|$360.007). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed: 23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:CFL1

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.96ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cofilin-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P23528

MASS(Da):18,502

GeneID:1072

Synonyms:18 kDa phosphoprotein;CFL 1;CFL1;Cofilin, non-muscle isoform;Cofilin-1;p18

Gene names:CFL1

Standard solution:3200ng/L