Human Claudin 1, CLDN1 ELISA Kit

SKU: E2300Hu

Size:96 Tests-1 Kit

Background:Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed: 23407391). (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes (PubMed: 17325668, PubMed: 20375010, PubMed: 24038151). Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell (PubMed: 20375010). Acts as a receptor for dengue virus (PubMed: 24074594).

Research_area:Immunology

Applications:ELISA

Target_protein:CLDN1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.22ng/ml

Detection range:0.5-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Claudin 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O95832

MASS(Da):22,744

GeneID:9076

Synonyms:Claudin-1;CLDN 1;CLDN1;Senescence-associated epithelial membrane protein

Gene names:CLDN1

Standard solution:48ng/ml