Human CD46 ELISA Kit PicoKine®

SKU: EK2194

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CD46

Specificity: Natural and recombinant Human CD46

Background: CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Immunogen: Expression system for standard: NS0; Immunogen sequence: C35-L392

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Reference:

Uniprot ID: P15529

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 4179

Protein Name: Membrane cofactor protein

Gene Full Name: CD46 molecule

Synonyms: CD46; MCP; Membrane cofactor protein; MIC10; TLX; TRA2.10