Human CD206/CLEC13D PicoKine® Quick ELISA Kit

SKU: FEK2049

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: MRC1

Specificity: Natural and recombinant Human MRC1

Background: The mannose receptor (Cluster of Differentiation 206, CD206) is a C-type lectin primarily present on the surface of macrophages and immature dendritic cells, but is also expressed on the surface of skin cells such as human dermal fibroblasts and keratinocytes. It is the first member of a family of endocytic receptors that includes Endo180 (CD280), M-type PLA2R, and DEC-205 (CD205). This gene is mapped to 10p12.33. The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.

Immunogen: Expression system for standard: NS0; Immunogen sequence: L19-K1383

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Reference:

Uniprot ID: P22897

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 4360

Protein Name: Macrophage mannose receptor 1

Gene Full Name: mannose receptor C-type 1

Synonyms: CD206; CLEC13D; Macrophage mannose receptor 1; Mannose receptor; mannose receptor; C type 1; MMR; MRC1