Human Cd177 Antigen, CD177 ELISA Kit

SKU: E5016Hu

Size:96 Tests-1 Kit

Background:In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369).

Research_area:Immunology

Applications:ELISA

Target_protein:CD177

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.26ng/ml

Detection range:0.5-100ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:CD177 antigen

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8N6Q3

MASS(Da):46,363

GeneID:57126

Synonyms:CD antigen CD177;CD177;CD177 antigen;HNA2A;HNA-2a;Human neutrophil alloantigen 2a;NB1;NB1 glycoprotein;NB1 GP;Polycythemia rubra vera protein 1;PRV1;PRV-1

Gene names:CD177

Standard solution:128ng/ml