Human CD169/SIGLEC-1/Sialoadhesin ELISA Kit PicoKine®

SKU: EK1304

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: SIGLEC1

Specificity: Natural and recombinant human CD169

Background: SIGLEC-1, also known as Sialoadhesin or CD169, is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. This gene is mapped to 20p13. It belongs to the immunoglobulin superfamily (IgSF). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. The localization and expression of SIGLEC-1 in humans has altered coincident with the evolutionary loss of Neu5Gc. SIGLEC-1-positive macrophages have a dual physiologic function. They act as innate 'flypaper' by preventing the systemic spread of lymph-borne pathogens and as critical gatekeepers at the lymph-tissue interface that facilitate the recognition of particulate antigens by B cells and initiate humoral immune responses.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S20-Q1641

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Reference:

Uniprot ID: Q9BZZ2

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 6614

Protein Name: Sialoadhesin

Gene Full Name: sialic acid binding Ig like lectin 1

Synonyms: CD169; Sialoadhesin; SIGLEC 1; SIGLEC1; SN