Human CD13/Aminopeptidase N ELISA Kit PicoKine®

SKU: EK1216

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: ANPEP

Specificity: Natural and recombinant human CD13

Background: Alanine aminopeptidase, also known as ANPEP or CD13. is an enzyme that is used as a biomarker to detect damage to the kidneys, and that may be used to help diagnose certain kidney disorders. It is mapped to 15q26.1. Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine, Aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases, and it is also thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Petrovic et al showed that CD13 was required for endothelial cell invasion in response to bradykinin. Inhibition of CD13 abrogated internalization of bradykinin receptor B2 and reduced endothelial cell motility.

Immunogen: Expression system for standard: NS0; Immunogen sequence: K69-K967

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Reference:

Uniprot ID: P15144

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 290

Protein Name: Aminopeptidase N

Gene Full Name: alanyl aminopeptidase, membrane

Synonyms: Alanyl aminopeptidase; Aminopeptidase M; Aminopeptidase N; ANPEP; AP M; AP N; APN; CD13; gp150; hAPN; LAP1; Microsomal aminopeptidase; p150; PEPN