Human Cc-Chemokine Receptor 2, CCR-2 ELISA Kit

SKU: E3599Hu

Size:96 Tests-1 Kit

Background:Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (PubMed: 8146186, PubMed: 8048929, PubMed: 23408426). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed: 23938203). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Research_area:Immunology

Applications:ELISA

Target_protein:CCR2

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.78ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cc-Chemokine Receptor 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P41597

MASS(Da):41,915

GeneID:729230

Synonyms:C-C chemokine receptor type 2;C-C CKR-2;CC-CKR-2;CCR 2;CCR2;CCR-2;CD antigen CD192;MCP-1-R;Monocyte chemoattractant protein 1 receptor;

Gene names:CCR2

Standard solution:3200ng/L