Human Catenin Alpha 1, CTNNA1 ELISA Kit

SKU: E2389Hu

Size:96 Tests-1 Kit

Background:Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:CTNNA1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.054ng/ml

Detection range:0.1-35ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Catenin Alpha 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P35221

MASS(Da):100,071

GeneID:1495

Synonyms:Alpha E-catenin;Cadherin-associated protein;Catenin alpha-1;CTNNA 1;CTNNA1;Renal carcinoma antigen NY-REN-13

Gene names:CTNNA1

Standard solution:40ng/ml