Human Caspase 8/CASP8 ELISA Kit PicoKine®

SKU: EK1426

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CASP8

Specificity: Natural and recombinant human Caspase 8

Background: Caspase-8 is a caspase protein, encoded by the CASP8 gene. It is mapped to human chromosome 2q33-q34 and mouse chromosome 1B-proximal C. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. And this protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: S217-D384 & L385-D479

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Reference:

Uniprot ID: Q14790

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 841

Protein Name: Caspase-8

Gene Full Name: caspase 8

Synonyms: Apoptotic protease Mch 5; Casp 8; CASP8; CASP-8; Caspase 8; caspase8; FADD like ICE; FLICE; ICE like apoptotic protease 5; MCH5