Human Cartilage Intermediate Layer Protein 1, CILP ELISA Kit

SKU: E6610Hu

Size:96 Tests-1 Kit

Background:Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:CILP

Reactivity:Human

Assay type:Sandwich

Sensitivity:26.34ng/L

Detection range:50-10000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cartilage Intermediate Layer Protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75339

MASS(Da):132,565

GeneID:8483

Synonyms:Cartilage intermediate layer protein 1;Cartilage intermediate layer protein 1 C1;Cartilage intermediate layer protein 1 C2;Cartilage intermediate-layer protein;CILP;CILP-1

Gene names:CILP

Standard solution:12800ng/L