Human Calcium-binding and coiled-coil domain-containing protein 2,CALCOCO2 ELISA KIT

SKU: E7387Hu

Size:96 Tests-1 Kit

Background:Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994). {ECO:0000269|PubMed:17635994, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:23022382, ECO:0000269|PubMed:23386746, ECO:0000269|PubMed:25771791}.

Research_area:

Applications:ELISA

Target_protein:CALCOCO2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.28ng/ml

Detection range:0.5-200ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Calcium-binding and coiled-coil domain-containing protein 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13137

MASS(Da):52254

GeneID:10241

Synonyms:CALCOCO2 NDP52

Gene names:CALCOCO2

Standard solution:240ng/ml