Human Cadherin 5,CDH5 ELISA KIT

SKU: E7006Hu

Size:96 Tests-1 Kit

Background:Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (PubMed:20332120). Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (PubMed:20332120). {ECO:0000250|UniProtKB:P55284, ECO:0000250|UniProtKB:Q8AYD0, ECO:0000269|PubMed:10861224, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}.

Research_area:

Applications:ELISA

Target_protein:CDH5

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.096ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Cadherin 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P33151

MASS(Da):87528

GeneID:1003

Synonyms:CDH5

Gene names:CDH5

Standard solution:64ng/ml