Human C-C Motif Chemokine 5, CCL5/RANTES ELISA Kit

SKU: E5009Hu

Size:96 Tests-1 Kit

Background:Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed: 16791620, PubMed: 1380064, PubMed: 8525373, PubMed: 9516414, PubMed: 15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed: 23979485).

Research_area:Immunology; Cardiovascular

Applications:ELISA

Target_protein:CCL5

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.26ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:C-C Motif Chemokine 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P13501

MASS(Da):9,990

GeneID:6352

Synonyms:C-C motif chemokine 5;CCL 5;CCL5;EoCP;Eosinophil chemotactic cytokine;RANTES(3-68;RANTES(4-68;SIS-delta;Small-inducible cytokine A5;T cell-specific protein P228;T-cell-specific protein RANTES;TCP228

Gene names:CCL5

Standard solution:2400ng/L