Human C-C Motif Chemokine 20, CCL20 ELISA Kit

SKU: E6513Hu

Size:96 Tests-1 Kit

Background:Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed: 11352563, PubMed: 11035086, PubMed: 20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed: 21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed: 9038201, PubMed: 11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed: 11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed: 23765988, PubMed: 25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed: 9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed: 12149255).

Research_area:Immunology

Applications:ELISA

Target_protein:CCL20

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.95ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:C-C Motif Chemokine 20

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P78556

MASS(Da):10,762

GeneID:6364

Synonyms:Beta-chemokine exodus-1;CC chemokine LARC;C-C motif chemokine 20;CCL 20;CCL20;CCL20(1-64;CCL20(1-67;CCL20(2-70;Liver and activation-regulated chemokine;Macrophage inflammatory protein 3 alpha;MIP-3-alpha;Small-inducible cytokine A20

Gene names:CCL20

Standard solution:2400ng/L