Human Bone Morphogenetic Protein 5, BMP5 ELISA Kit

SKU: E2244Hu

Size:96 Tests-1 Kit

Background:Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:29321139, PubMed:11580864). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566).

Research_area:Cardiovascular; Signal Transduction; Cell Biology

Applications:ELISA

Target_protein:BMP5

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.88ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Bone Morphogenetic Protein 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P22003

MASS(Da):51,737

GeneID:653

Synonyms:BMP 5;BMP5;BMP-5;Bone morphogenetic protein 5

Gene names:BMP5

Standard solution:2400ng/L